Right Ventricular Physiology, Adaptation and Failure in Congenital and Acquired Heart Disease by Mark K. Friedberg & Andrew N. Redington

Author:Mark K. Friedberg & Andrew N. Redington
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Alternative NO-Based Therapies

Nitrite was until recently considered a physiologically inert by-product of NO oxidation. It is now apparent that circulating nitrite is recycled in tissues to form NO, thereby acting as a stable endocrine pool for “NO-like” bioactivity that is complementary to endogenous NOS [127]. Systemic or inhaled inorganic nitrite possesses many theoretical advantages over other forms of NO-based therapy in that tachyphylaxis does not occur with chronic dosing, effects are of relatively rapid onset and last many hours and (sodium) nitrite is inexpensive and stable. Protective effects of sodium nitrite on adult experimental models of PHT have been reported [127–131] but no studies have been reported to date in neonatal animals.

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